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[89Zr]Zr-DFO-H4-Fc
- Development stage
- Preclinical
- Lead developer
- University of Wisconsin–Madison
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Gamma Emitters → Radiopharmaceuticals, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
[89Zr]Zr-DFO-H4-Fc is a radiolabeled immuno-PET imaging agent developed by the University of Wisconsin-Madison. It consists of H4-Fc, a nurse shark-derived variable new antigen receptor (VNAR) single-domain antibody fused to a human IgG1 Fc scaffold, which is site-specifically conjugated to a deferoxamine (DFO) chelator and radiolabeled with the positron-emitting isotope zirconium-89 ([89Zr]Zr). The agent specifically targets fibroblast activation protein alpha (FAP), a cell-surface serine protease highly expressed on activated fibroblasts at sites of tissue remodeling, chronic inflammation, peripheral nerve injury, and in the tumor microenvironment of solid tumors. [89Zr]Zr-DFO-H4-Fc is being investigated in preclinical studies as a diagnostic tool to non-invasively detect and localize chronic neuropathic pain and neuroinflammation, as well as for potential theranostic applications in oncology.
- Other names
- 89Zr-DFO-H4-Fc[89Zr]Zr-H4-FcH4-FcH-4-FcH 4-Fc
02
Targets
FAP (Fibroblast activation protein alpha)
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